Writing in the BMJ Blog, George Alleyne, director emeritus of the Pan American Health Organization (PAHO), reflects on global health challenges and opportunities, writing, “There have been massive changes not only in the basic health problems, but also in how we have addressed them.” Some health issues, such as HIV, “have such political ramifications outside of health that they need to be addressed in a global political forum,” he writes, adding, “Thus health is entering the global political arena.” Alleyne goes on to discuss the importance of cooperation and partnership among government, business, and academia (12/4).