The PLOS “Speaking of Medicine” blog highlights a number of new articles published in the current issue of PLOS Medicine. Jessica Haberer and colleagues report that high adherence to antiretroviral pre-exposure prophylaxis (PrEP) for people in serodiscordant relationships, “achieved in the setting of active adherence monitoring and counseling support, is associated with a high level of protection from HIV acquisition by the HIV-uninfected partner”; Silvy Peeters and Anna Gilmore “explore the motivation behind tobacco companies’ interests in smokeless tobacco products in Europe”; and “Iza Ciglenecki and colleagues from Médecins Sans Frontières (Doctors without Borders) describe their experience of undertaking the first mass vaccination campaign using oral cholera vaccines in response to an outbreak in Guinea,” according to the blog (9/10).