The U.S. Government and Global Neglected Tropical Disease Efforts

Key Facts

  • Neglected tropical diseases (NTDs) are a set of infectious diseases grouped together due to their often chronic, disfiguring, and stigmatizing impact; their close association with poverty; and their geographic overlap.
  • While there are numerous NTDs in the world, the World Health Organization (WHO) has highlighted 20 that particularly impact poor, politically marginalized populations; cause significant morbidity and/or mortality; are neglected by research; and can be controlled using effective methods.1
  • In recent years, the U.S. government (U.S.) has affirmed its support for global NTD goals, including eradicating, eliminating, and controlling several NTDs.2
  • The U.S. has become more involved in global NTDs since launching its first NTD program in 2006 at the U.S. Agency for International Development (USAID) with a focus on seven NTDs that are responsible for the overwhelming majority of the NTD burden but can be controlled and even eliminated with low-cost and effective interventions.
  • Total U.S. funding for NTDs increased from $15 million in FY 2006, which was the first year Congress appropriated funds for NTDs, to $103 million in FY 2020.

Global Situation

NTDs have garnered greater attention from the U.S. government and other global donors over the last decade, spurred on by growing recognition of their potential threat to the achievement of the Millennium Development Goals (MDGs) and their successor, the Sustainable Development Goals (SDGs).3 In addition, the development and expansion of an integrated NTD treatment approach capitalized on the availability of safe and effective treatments for the most prevalent NTDs.

Neglected Tropical Diseases (NTDs): A group of parasitic, bacterial, and viral infectious diseases that primarily affect the most impoverished and vulnerable populations in the world and, as such, have received scant attention until the past decade.4

NTDs are among the top 10 major communicable disease causes of ill health globally, behind lower respiratory infections, diarrheal diseases, HIV, tuberculosis, and malaria.5 NTDs are grouped together due to their often chronic, disfiguring, and stigmatizing impact; their close association with poverty; and their geographic overlap.

Impact

NTDs have low mortality but high morbidity rates.6 More than a billion people – one-sixth of the world’s population – are infected with one or more NTDs, and an additional two billion are at risk. Each year, about 185,000 people die as a result.7 Infection with an NTD may result in severe disability, disfigurement, blindness, and malnutrition, and individuals are often infected with multiple NTDs simultaneously. The health impact of NTDs negatively affects economic development, hampers educational achievement and cognitive development, and reduces agricultural productivity and food security.8

Endemic to almost 150 countries, NTDs span the globe.9 However, the majority of the NTD burden is concentrated in low- and middle-income countries in Africa, Asia, and Latin America.10 People living in rural areas as well as urban slums are among the most affected, since lack of access to clean water, health services, adequate housing, and good sanitation contribute to NTDs’ prevalence and impact. Women and children are most at risk of infection, since they are more exposed to NTDs and more often face barriers to accessing treatment, particularly those living in remote areas.11

Major NTDs

While there are numerous NTDs in the world, the World Health Organization (WHO) has highlighted 20 that particularly impact poor, politically marginalized populations; cause significant morbidity and/or mortality; are neglected by research; and can be controlled using effective methods.12

Seven “tool-ready” NTDs, those that can be controlled and even eliminated due to the availability of low-cost and effective interventions, are responsible for the overwhelming majority of the NTD burden (see Table 1). This subset of NTDs is increasingly the focus of donor efforts, including USAID’s NTD Program.

Table 1: Seven NTDs Targeted by USAID’s NTD Program13
Disease # of People Affected
Each Year
# of Affected Countries Causes
Soil-Transmitted Helminths
(STH):
1,500 million+ 112 Infection with worms transmitted through ingestion of or direct exposure to soil that is contaminated by human feces in which STH eggs are present.
   Ascariasis (roundworm) 819 million Infection typically due to ingesting contaminated soil, food, or water
   Hookworm 439 million Infection typically due to walking barefoot on contaminated soil or ingesting larvae
   Trichuriasis (whipworm) 465 million Infection typically due to ingesting contaminated soil or food
Lymphatic filariasis
(elephantiasis)
36 million 49 Infection with worms transmitted by mosquitoes
Onchocerciasis
(river blindness)
21 million 34 Infection with worms transmitted by black flies that breed near fast-moving rivers and streams
Schistosomiasis
(snail fever)
102 million 78 Infection with worms transmitted through contaminated freshwater inhabited by snails carrying the parasite
Trachoma 1.9 million* 44 Infection transmitted through direct or indirect contact with bacteria in an infected person’s eye or nasal discharge (on hands/clothes or on the feet of flies)
NOTES: — indicates the information in not available; * indicates active trachoma, trichiasis, and irreversible blindness due to trachoma.

Interventions

A number of strategies have been successful in controlling and, in some areas, even eliminating certain NTDs. Although many interventions are relatively inexpensive, challenges persist in delivering tools and services to the most at-risk populations.

Today, the recommended strategy is an integrated control approach targeting multiple NTDs simultaneously through mass drug administration (MDA), combined with community-level transmission control measures. This allows programs to reach more people and increase cost-efficiencies over tackling each disease separately.14 MDA often uses the “rapid-impact package,” which is a combination of four drugs used to prevent or treat the seven most prevalent NTDs for as little as $0.10-$0.50 per person per year.15 The low cost of the rapid-impact package is partially due to donations of drug treatments from pharmaceutical companies, which have risen by more than 35% since 2011.16 Additional measures such as promoting clean water, sanitation, and hygiene (WASH) and good veterinary public health also play critical roles in addressing the underlying causes of NTDs.17

Global Goals

As NTDs began to receive greater attention and global efforts have expanded over the past ten years, major global NTD goals have been set through:

2012 WHO Roadmap for Implementation

The Roadmap outlined targets and strategies for global NTD control, elimination, and eradication efforts from 2012 through 2020. Among its goals was the eradication of dracunculiasis (Guinea worm disease) by 2015, which was not achieved but WHO reports the world is on the verge of eradicating the disease, with only 28 cases in 2018.18 Other goals are the eradication of yaws by 2020 and elimination of four NTDs – blinding trachoma, human African trypanosomiasis (sleeping sickness), leprosy, and lymphatic filariasis (LF) – by 2020.19

London Declaration on Neglected Tropical Diseases20

The Declaration was endorsed by key public and private stakeholders in 2012 and laid out global NTD goals (affirming those in the Roadmap) and commitments. It aims to improve partner efforts to coordinate and collaborate across their respective efforts in order to help eradicate Guinea worm disease and, by 2020, to help to eliminate the four NTDs mentioned above (blinding trachoma, sleeping sickness, leprosy, and LF) and to control schistosomiasis, soil-transmitted helminths, Chagas disease, visceral leishmaniasis, and onchocerciasis.21 In 2017, stakeholders attending the NTD Summit reaffirmed their London Declaration commitments through the Geneva Commitment.22

SDG 3: End the Epidemic of NTDs

Adopted in 2015 by all member-states of the United Nations, the Sustainable Development Goals (SDGs) included a target of ending the epidemic of NTDs by 2030 as part of SDG 3 (“ensure healthy lives and promote well-being for all at all ages”).23 The SDGs are the successor to the Millennium Development Goals (MDGs), which did not include a specific NTD indicator.24

U.S. Government Efforts

Over the past fifteen years, U.S. attention to and funding for NTDs have increased markedly. Historically, the U.S. government’s response to NTDs was relatively limited, focusing largely on research and surveillance conducted by the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), and the Department of Defense (DoD). In 2006, Congress first appropriated funds to the U.S. Agency for International Development (USAID) for integrated NTD control, after which the agency launched its NTD Program. In 2008, the USG announced expanded NTD efforts, building on USAID’s NTD Program.25 In 2012, the U.S. signed onto the London Declaration, and more recently, the U.S. adopted a longer term global health goal of protecting communities from infectious diseases and highlighted the important role of NTD efforts in achieving this goal.26

Organization

USAID serves as the lead implementing agency for U.S. NTD efforts. Several other agencies, including NIH, CDC, DoD, and the U.S. Food and Drug Administration (FDA), are also involved in responding to NTDs worldwide. Collectively, U.S. activities reach more than 30 countries.27

USAID28

USAID’s NTD Program targets seven “tool-ready” NTDs (see Table 1). Having scaled up from five countries in 2006, it now spans 26 countries, mostly in sub-Saharan Africa and Southeast Asia, and has one regional program, which reaches an additional six countries in the Americas. Using interventions such as the rapid-impact package, the USG supports endemic countries in scaling up MDA and developing their capacity to manage NTD control programs. The program’s goals are to eliminate LF and blinding trachoma globally by 2020 and to increase integrated, sustainable delivery of preventive chemotherapy for all NTDs.

Other U.S. Efforts

Other agencies support research and development (R&D) activities related to and efforts focused on encouraging adoption of control tools for NTDs, including the seven targeted NTDs as well as others not yet considered “tool-ready” (Buruli ulcer, Chagas disease, dengue, human African trypanosomiasis, leishmaniasis).29 NIH, CDC, and DoD support various NTD R&D efforts,30 while the FDA administers the congressionally-authorized Tropical Disease Priority Review Program,31 which “provides for a voucher that is awarded at the time of approval of certain drugs that prevent or treat” an NTD.32 The voucher, which can subsequently “be redeemed for a priority review of an application for a drug for any indication submitted at a later time,”33 is designed as an incentive for the private sector to invest in new NTD drug development.34 A number of vouchers have already been authorized by the FDA.35 Additionally, CDC provides technical assistance to countries and other partners, helps to develop guidelines for NTD control, and aids efforts to monitor and evaluate progress.36

Multilateral and Other Efforts

U.S. NTD efforts are coordinated with a number of international partners (like WHO and private sector entities), regional strategies (like the Regional Strategy on NTDs in the WHO African Region 2014-2020), and funding mechanisms (like the END Fund).37 For example, the pharmaceutical industry donates several NTD drugs to many of the countries that also receive USAID NTD support; USAID has estimated the value of these donations in U.S.-supported countries at approximately $22 billion since 2006.38

Funding39

Total U.S. funding for NTDs increased from $15 million in FY 2006, which was the first year Congress appropriated funds for NTDs, to $103 million in FY 2020 (see Figure 1). The current Administration had requested $75 million in funding for NTDs for FY 2020, a significant decrease from prior years, but Congress maintained level funding. U.S. funding for NTDs is provided through the Global Health Programs account at USAID.40

Figure 1: U.S. Funding for Global Neglected Tropical Diseases (NTDs), FY 2006 – FY 2020

Key Issues for the U.S.

Over the past decade, U.S. global NTD efforts and funding have expanded, as have those of other entities. Today, U.S. NTD efforts are an important part of the U.S. global health agenda. Looking ahead, there are several issues and challenges facing U.S. NTD efforts, starting with questions about the extent to which the current Administration will continue to support ongoing efforts, particularly in light of FY 2020 budget proposal to significantly reduce NTD funding, but also including:

  • sustaining and augmenting successes, such as expanding the availability of low-cost and effective interventions to control and even eliminate some NTDs;
  • realizing further cost efficiency savings;
  • securing additional donated drugs;
  • strengthening countries’ capacity to conduct intensified case detection and management and to manage morbidity, disability, and disfigurement related to some NTDs;
  • supporting improved monitoring, disease mapping, and evaluation of global progress;
  • addressing outstanding research challenges, including identifying cost-effective interventions for NTDs not yet “tool-ready;”
  • further integrating NTD efforts with other U.S. global health programs, such as HIV/AIDS, TB, and malaria programs; and
  • improving coordination among the U.S. government and other donors and stakeholders.
Endnotes
  1. WHO: Working to Overcome the Global Impact of NTDs, 2010; WHO, “Neglected tropical diseases – Summary,” webpage, http://www.who.int/neglected_diseases/diseases/summary/en/; WHO, “Neglected tropical diseases – Diseases,” webpage, http://www.who.int/neglected_diseases/diseases/en/. The 20 are: Buruli ulcer; Chagas disease; dengue; dracunculiasis (Guinea worm disease); echinococcosis; foodborne trematode infections; human African trypanosomiasis (sleeping sickness); leishmaniasis; leprosy; lymphatic filariasis; mycetoma, chromoblastomycosis and other deep mycoses; onchocerciasis (river blindness); rabies; scabies and other ectoparasites; schistosomiasis; snakebite envenoming; soil-transmitted helminths; taeniasis/neurocysticercosis; trachoma; and yaws.

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  2. The London Declaration on Neglected Tropical Diseases, Jan. 30, 2012.

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  3. United Nations, The Millennium Development Goals Report 2008, Sept. 2008; Congressional Research Service (CRS), Neglected Tropical Diseases: Background, Responses, and Issues for Congress, Jan. 2011; CRS, Progress in Combating Neglected Tropical Diseases (NTDs): U.S. and Global Efforts from FY2006 to FY2015, May 2014; Global Network, “NTDs and the Millennium Development Goals,” fact sheet, undated.

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  4. WHO, Neglected Tropical Diseases: Hidden Successes, Emerging Opportunities, 2009; USAID’s NTD Program website, www.neglecteddiseases.gov; Peter Hotez, et al., “Control of Neglected Tropical Diseases,” NEJM, Vol. 357 (10), 2007; CDC, “Neglected Tropical Diseases,” webpage, http://www.cdc.gov/globalhealth/ntd/.

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  5. Based on WHO, “Global Health Estimates 2016: DALYs by cause globally, 2016 and 2000,” Global Health Estimates 2016 Summary Tables, 2018, http://www.who.int/healthinfo/global_burden_disease/GHE2016_DALY_Global_2000_2016_.xls?ua=1.

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  6. WHO, Integrating Neglected Tropical Diseases into Global Health and Development, 2017.

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  7. Based on WHO, “Global Health Estimates 2016: Estimated deaths by cause, 2000 and 2016,” Global Health Estimates 2016 Summary Tables, 2018, http://www.who.int/healthinfo/global_burden_disease/GHE2016_Deaths_Global_2000_2016.xls?ua=1. See also WHO, Investing to Overcome the Global Impact of NTDs, 2015; WHO, Integrating Neglected Tropical Diseases into Global Health and Development, 2017.

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  8. Peter Hotez, et al., “Rescuing the bottom billion through control of neglected tropical diseases,” Lancet, Vol. 373, 2009.

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  9. WHO: “Neglected tropical diseases: diseases,” webpage, http://www.who.int/neglected_diseases/diseases/en/; Neglected Tropical Diseases: Hidden Successes, Emerging Opportunities, 2009; Investing to Overcome the Global Impact of NTDs, 2015.

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  10. WHO, Neglected Tropical Diseases: Hidden Successes, Emerging Opportunities, 2009; USAID’s NTD Program website, www.neglecteddiseases.gov; WHO, Investing to Overcome the Global Impact of NTDs, 2015; CDC, “Neglected Tropical Diseases: Diseases” webpage, https://www.cdc.gov/globalhealth/ntd/diseases/index.html.

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  11. For example, young children are the principal reservoir of trachoma infection, and due to the role of women as caretakers of children, there is an increased likelihood of being infected with trachoma multiple times. Women are up to 4 times more likely to be blinded by trachoma than men. WHO, “Trachoma,” fact sheet, Feb. 2018 and April 2017; WHO, Investing to Overcome the Global Impact of NTDs, 2015; WHO, Neglected Tropical Diseases: Hidden Successes, Emerging Opportunities, 2009; USAID’s NTD Program website, www.neglecteddiseases.gov; WHO, “Blinding Trachoma,” March 2015.

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  12. WHO: Working to Overcome the Global Impact of NTDs, 2010; WHO, “Neglected tropical diseases – Summary,” webpage, http://www.who.int/neglected_diseases/diseases/summary/en/; WHO, “Neglected tropical diseases – Diseases,” webpage, http://www.who.int/neglected_diseases/diseases/en/. The 20 are: Buruli ulcer; Chagas disease; dengue; dracunculiasis (Guinea worm disease); echinococcosis; foodborne trematode infections; human African trypanosomiasis (sleeping sickness); leishmaniasis; leprosy; lymphatic filariasis; mycetoma, chromoblastomycosis and other deep mycoses; onchocerciasis (river blindness); rabies; scabies and other ectoparasites; schistosomiasis; snakebite envenoming; soil-transmitted helminths; taeniasis/neurocysticercosis; trachoma; and yaws.

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  13. WHO, Neglected Tropical Diseases: Hidden Successes, Emerging Opportunities, 2009; Peter Hotez, et al., “Control of Neglected Tropical Diseases,” NEJM, Vol. 357 (10), 2007; WHO fact sheets: “Soil-transmitted helminth infections,” Jan. 2017 and March 2019; “Lymphatic filariasis,” Oct. 2019; “Schistosomiasis,” April 2019; “Onchocerciasis,” Nov. 2018 and June 2019; “Trachoma,” June 2019; WHO, “Neglected tropical diseases – Summary,” webpage, http://www.who.int/neglected_diseases/diseases/summary/en/; WHO, Investing to Overcome the Global Impact of NTDs, 2015; WHO, Integrating Neglected Tropical Diseases into Global Health and Development, 2017; USAID’s NTD Program website, www.neglecteddiseases.gov; Rachel Pollan, et al., “Global numbers of infection and disease burden of soil transmitted helminth infections in 2010,” Parasites & Vectors, Vol. 7: 37, 2014.

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  14. USAID, “Portfolio Review: Neglected Tropical Diseases,” presentation, Feb. 17, 2011.

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  15. Peter Hotez, et al., “Control of Neglected Tropical Diseases,” NEJM, Vol. 357 (10), 2007; Mary Linehan, et al., “Integrated Implementation of Programs Targeting NTDs through Preventive Chemotherapy: Proving the Feasibility at National Scale,” AJTMH, Vol. 84 (1), 2011; WHO, Investing to Overcome the Global Impact of NTDs, 2015; CDC, “Neglected Tropical Diseases: Diseases” webpage, https://www.cdc.gov/globalhealth/ntd/diseases/index.html.

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  16. Peter Hotez, et al., “Control of Neglected Tropical Diseases,” NEJM, Vol. 357 (10), 2007; Uniting to Combat NTDs, Country Leadership and Collaboration on Neglected Tropical Diseases, 2015; Uniting to Combat NTDs, Delivering on Promises and Driving Progress, 2014.

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  17. WHO, Integrating Neglected Tropical Diseases into Global Health and Development, 2017; WHO, Investing to Overcome the Global Impact of NTDs, 2015; USAID’s NTD Program website, www.neglecteddiseases.gov.

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  18. Carter Center, “Guinea Worm Case Totals,” webpage, https://www.cartercenter.org/health/guinea_worm/case-totals.html; WHO, “Dracunculiasis (guinea-worm disease),” fact sheet, April 2018.

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  19. WHO, Accelerating Work to Overcome the Global Impact of Neglected Tropical Diseases: A Roadmap for Implementation, 2012.

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  20. The London Declaration on Neglected Tropical Diseases, Jan. 30, 2012.

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  21. The London Declaration on Neglected Tropical Diseases, Jan. 30, 2012. The Roadmap and the Declaration were subsequently acknowledged in 65th World Health Assembly, “Neglected tropical diseases,” resolution 66.12, May 27, 2013. See also Uniting to Combat NTDs, Reaching a Billion, Ending Neglected Tropical Diseases: A gateway to Universal Health Coverage, Fifth progress report on the London Declaration on NTDs, Dec. 2017.

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  22. The Geneva Commitment, April 2017, https://unitingtocombatntds.org/resources/geneva-commitment/.

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  23. UN, Transforming our world: the 2030 Agenda for Sustainable Development, 2015.

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  24. UN, “Official List of MDG Indicators,” webpage, http://unstats.un.org/unsd/mdg/Host.aspx?Content=Indicators/OfficialList.htm.

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  25. White House, “President Bush Announces New Global Initiative for Combating Neglected Tropical Diseases,” press release, Feb. 20, 2008; USAID’s NTD Program website, www.neglecteddiseases.gov; CRS, Neglected Tropical Diseases: Background, Responses, and Issues for Congress, Jan. 2011.

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  26. USAID Global Health Programs website, https://www.usaid.gov/what-we-do/global-health; USAID, Annual Progress Report to Congress: Global Health Programs FY 2013, 2014.

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  27. USAID’s NTD Program website, www.neglecteddiseases.gov; USAID, “Working to Protect Against Neglected Tropical Diseases,” fact sheet, updated July 25, 2018; CDC, “Neglected Tropical Diseases: CDC’s Role,” webpage, http://www.cdc.gov/globalhealth/ntd/cdc_role/index.html. Other USG efforts may reach additional countries.

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  28. USAID, “Neglected Tropical Diseases,” webpage, http://www.usaid.gov/what-we-do/global-health/neglected-tropical-diseases; USAID, “Working to Protect Against Neglected Tropical Diseases,” fact sheet, updated 2019; USAID, “Neglected Tropical Diseases,” fact sheet, updated March 21, 2016; USAID’s NTD Program website, www.neglecteddiseases.gov; USAID, USAID Neglected Tropical Disease Program 2016 Evaluation, March 2018.

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  29. WHO, “NTDs: Innovative and Intensified Disease Management,” 2007.

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  30. NIH/NIAID, “NIAID Role in Neglected Tropical Diseases (NTD) Research,” webpage, https://www.niaid.nih.gov/research/niaid-role-neglected-tropical-diseases-ntd-research; CDC, “Neglected Tropical Diseases: CDC’s Role,” webpage, http://www.cdc.gov/globalhealth/ntd/cdc_role/index.html; CDC, “Neglected Tropical Diseases Program,” fact sheet, updated April 19, 2017; KFF, The U.S. Department of Defense and Global Health: Infectious Disease Efforts, 2013; Department of Defense’s Naval Medical Research Center, “Infectious Diseases,” webpage, http://www.med.navy.mil/sites/nmrc/NMRC/NMRC_Offices/Pages/IDD.aspx.

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  31. FDA, “Tropical Disease Priority Review Voucher Program,” webpage, https://www.fda.gov/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDER/ucm534162.htm.

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  32. FDA, Guidance for Industry: Neglected Tropical Diseases of the Developing World: Developing Drugs for Treatment or Prevention, July 2014; U.S. Congress: Adding Ebola to the FDA Priority Review Voucher Program Act (P.L. 113-233), Dec. 12, 2014; Adding Zika Virus to the FDA Priority Review Voucher Program Act (P.L. 114-146), April 19, 2016.

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  33. FDA: Guidance for Industry: Neglected Tropical Diseases of the Developing World: Developing Drugs for Treatment or Prevention, July 2014; Guidance for Industry: Tropical Disease Priority Review Vouchers, October 2016.

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  34. Per Jesse L. Goodman, FDA Chief Scientist, “Working Together to Address the Challenges of Rare and Neglected Diseases,” Testimony before the House Foreign Affairs Committee’s Subcommittee on Africa, Global Health, Global Human Rights, and International Organizations, June 27, 2013, “FDA has long had in place a review system to ensure that the most critical medical products are reviewed on a priority basis. The goal for Priority Review applications for products that offer major advances in treatment, or provide a treatment when no adequate therapy exists, is to complete them within a six-month period, compared to the 10-month goal for standard review of other products. The Food and Drug Administration Amendments Act of 2007 (FDAAA) granted FDA the authority, beginning in 2009, to award Priority Review vouchers to a company that submits and, after review, receives marketing approval for certain products for one of 16 neglected ‘tropical’ diseases listed in the legislation. If transferred to apply to a blockbuster drug, the four months of earlier market access available when a Priority Review voucher is redeemed could, in some circumstances, be very valuable.” See also FDA, Guidance for Industry: Tropical Disease Priority Review Vouchers, October 2016.

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  35. David Ripley, “Priority Review Vouchers,” webpage, http://priorityreviewvoucher.org/; Jonathan Berman and Tanya Radhakrishna, “The Tropical Disease Priority Review Voucher: A Game-Changer for Tropical Disease Products,” Am J Trop Med Hyg, Jan. 11, 2017, Vol. 96(1): 11-13.

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  36. CDC, “Neglected Tropical Diseases: CDC’s Role,” webpage, http://www.cdc.gov/globalhealth/ntd/cdc_role/index.html.

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  37. USAID’s NTD Program website, www.neglecteddiseases.gov; USAID, “Neglected Tropical Diseases,” fact sheet, Sept. 18, 2012 and update March 21, 2016; WHO Regional Office for Africa (AFRO), Regional Strategy on NTDs in the WHO African Region 2014-2020, 2014; AFRO, Regional Strategic Plan for Neglected Tropical Diseases in the African Region 2014–2020, 2013; The END Fund, http://www.end.org/; RTI International/Envision, “Neglected Tropical Diseases: The END Fund's Intervention in Mali,” http://www.ntdenvision.org/resource/neglected_tropical_diseases_the_end_funds_intervention_in_mali.

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  38. Through FY 2018. USAID’s NTD Program website, www.neglecteddiseases.gov; USAID, “Working to Protect Against Neglected Tropical Diseases,” fact sheet, updated 2019.

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  39. KFF analysis of data from the Office of Management and Budget, Agency Congressional Budget Justifications, Congressional Appropriations Bills, and the U.S. Foreign Assistance Dashboard website, ForeignAssistance.gov.

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  40. Represents specified funding for international NTD programs in the President’s budget request, ForeignAssistance.gov, and Congressional appropriations bills. Additional support for international NTD programs is provided through research activities at CDC and NIH.

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