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America First MOU Bilateral Global Health Agreements

On September 18, 2025, the U.S. government released its new America First Global Health Strategy, which details how the U.S. will engage in global health efforts moving forward. As part of this new strategy, the United States announced that it will be establishing bilateral health cooperation agreements with countries that receive U.S. global health assistance via Memorandums of Understanding (MOUs)

This tracker provides an overview of the MOUs signed to date. Data are based on press releases issued by the State Department, as specific details provided in the MOUs (i.e. program areas, financial breakdowns, data or specimen sharing agreements, etc.) are not yet publicly available. The tracker will be updated as agreements are signed and more data become available.

Questions for the America First Global Health Strategy

Global Health Budget Summaries

Overview of President Trump’s Executive Actions on Global Health

The Pause of Foreign Aid and Implications for PEPFAR and Other Global Health Programs

selected resources

Global Health Aid Cuts

This collection of resources chronicles what recent Trump administration global health aid cuts mean for the future of global health programs and the people who rely on them.

A promotional image for the the KFF Health Policy 101 U.S. Government and Global Health

The U.S. Government and Global Health

In this Health Policy 101 chapter, investigate the U.S. role in global health, including the major initiatives the United States supports, funding levels, and agencies involved in implementing program area efforts.

the essentials

Global Health Trackers

U.S. Global Health Budget Tracker

This tracker provides regularly updated information on U.S. government funding for global health. It includes historical trends and tracks funding levels for U.S. global health efforts through bilateral and multilateral contributions and by program area and agency.

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  • Africa CDC: Its Evolution and Key Issues for its Future

    Issue Brief

    This Issue Brief reviews the history of Africa CDC, describing its structure, funding and operations to date, including U.S. government engagement, as well as challenges and opportunities for the institution moving forward.

  • Global Health Funding in the FY 2024 President’s Budget Request

    Fact Sheet

    President Biden released the FY 2024 President’s Budget Request on March 9, 2023. The request includes discretionary funding for U.S. global health programs at the State Department, the U.S. Agency for International Development (USAID), the Centers for Disease Control and Prevention (CDC), and the National Institutes of Health (NIH).

  • PEPFAR Reauthorization 2023: Key Issues

    Policy Watch

    This year, Congress will consider reauthorization of the President’s Emergency Plan for AIDS Relief (PEPFAR). This Policy Watch provides fast facts about the program and top issues related to its authorization and funding.

  • Donor Government Funding for Family Planning in 2022

    Report

    This report provides an analysis of donor government funding to address family planning in low- and middle-income countries in 2022, which totaled US$1.35 billion and was a decline of 9% (US$129 million) compared to the 2021 amount (US$1.48 billion). While the decline was due to decreases in funding by most donor governments, a significant share can be attributed to exchange rate fluctuations resulting from the rise in value of the U.S. dollar against most currencies during 2022.

  • Donor Government Funding for Family Planning in 2023

    Report

    This report provides an analysis of donor government funding to address family planning in low- and middle-income countries in 2023, which totaled US$1.47 billion, and was an increase of 7% (US$101 million) compared to the 2022 amount (US$1.37 billion); although, it was still below the peak level reached in 2019 (US$1.58 billion). The overall increase was due to increased bilateral funding from most donor governments; multilateral funding (contributions to UNFPA’s core resources) declined slightly.

  • The Ground Has Shifted Under PEPFAR: What Does That Mean for Its Future?

    Perspective

    In this viewpoint article in the Journal of the International AIDS Society, KFF's Jennifer Kates and co-authors Brian Honermann and Gregorio Millett of amfAR explore the implications of shifts in the global economic and political environment for the future of PEPFAR, the U.S government's global HIV program created under President George W. Bush and credited with changing the trajectory of the global HIV/AIDS pandemic.

  • Administration Releases Additional Details of Fiscal Year 2026 Budget Request

    Fact Sheet

    On May 30, 2025, the administration released additional details of its Fiscal Year 2026 budget request, including more specific information on funding for global health activities at the State Department, U.S. Agency for International Development (USAID), Centers for Disease Control and Prevention (CDC), and the National Institutes of Health (NIH).