Opioid overdose deaths fell sharply from 2023 to 2024, driven largely by decreases in fentanyl-involved deaths.

Overall suicide deaths fell slightly from their peak, but firearm suicides reached their highest level and accounted for 57% of all suicides.

Alcohol deaths increased gradually before the pandemic, jumped in 2020 and 2021, and have fallen somewhat since then.

CDC data show that substance use and suicide deaths combined were the third leading cause of death in the U.S., behind heart disease and cancer.