AstraZeneca/Oxford Coronavirus Vaccine Shows 62% Efficacy With 2 Standard Doses, Data Published In Lancet Show

The Guardian: Oxford/AstraZeneca Covid vaccine has 70% efficacy, full trial data shows
“The Oxford/AstraZeneca Covid vaccine has efficacy of 90% in a small group who got a half-dose first, but only 62% in the majority, full trial data newly published in The Lancet has confirmed. The results may create a quandary for regulatory bodies, which will have to decide on how the vaccine should be used if they approve it…” (Boseley, 12/8).

STAT: Detailed data on AstraZeneca-Oxford Covid-19 vaccine show it has moderate efficacy
“…The results confirm that two standard doses of the vaccine were 62% effective in preventing symptomatic Covid-19 disease in some trials. But when efficacy data from the trials were combined — including trials in which volunteers received a low dose followed by a standard dose of vaccine — the vaccine was deemed to be 70% efficacious. Among only volunteers who received a low dose followed by a standard dose of vaccine, the vaccine had 90% efficacy. It’s still not clear why efficacy in this group — which did not include anyone over the age of 55 — was so high. Some experts even wonder if it is the result of the play of chance, and not a true difference…” (Branswell/Herper, 12/8).

Washington Post: AstraZeneca vaccine details published in Lancet, but data suggests need for more trials
“…Researchers also are still studying which dose regimen can produce the greatest protection. Still, the results show a safe, well-tolerated and effective vaccine, and one that is cheaper — at $2 or $3 a dose — and easier to manufacture, transport, and store than its competitors, Maria Deloria Knoll of the John Hopkins Bloomberg School of Public Health wrote in a commentary accompanying the article in The Lancet…” (Booth/Johnson, 11/8).

Additional coverage of the vaccine study results is available from Al Jazeera, Bloomberg, and Nature.

The KFF Daily Global Health Policy Report summarized news and information on global health policy from hundreds of sources, from May 2009 through December 2020. All summaries are archived and available via search.

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