Each year, the Kaiser Family Foundation and MTV jointly produce new PSAs to reach MTV viewers. These messages seek to raise awareness about the risk of HIV/AIDS and other STDs, and reduce their spread by encouraging more informed decision making, communication, protection, and testing among those who are sexually active.

The campaign, which has been recognized with an Emmy for best National PSA in 2002, 2003, 2004, and 2007 uses a variety of appeals and styles from upbeat and life-affirming to edgy and hard-hitting.

The ads are tagged with the campaign's toll-free hotline (1-877-777-ISYL) and website for viewers seeking additional information.

2007

Portraits- Goth Couple (:30) 56K 265K
Portraits- Straight Couple (:30) 56K 256K
World AIDS Day 2007 (:30) 56K 256K

2006

Marvelyn - First Meeting (:45) 56K 256K
Marvelyn - That Night (:45) 56K 256K
Marvelyn - Finding Out (:45) 56K 256K
Marvelyn - Denial (:45) 56K 256K
Marvelyn - The Guy (:45) 56K 256K
Marvelyn - Fairweather Friend (:45) 56K 256K
Marvelyn - Message (:10) 56K 256K
Marvelyn - Compilation (4:00) 56K 256K
The Speech (:45) 56K 256K
One of Those Guys (:45) 56K 256K
Basketball (:30) 56K 256K
Parallel Park (:30) 56K 256K
Father and Son (:40) 56K 256K
Mother and Daughter (:40) 56K 256K
Alive at 25 Vlogging Contest (:30) 56K 256K

2005

Andrew (:30) 56K 256K
Esko (:30) 56K 256K
Katie (:30) 56K 256K
Kehende (:30) 56K 256K
Marcus (:30) 56K 256K
Matt (:30) 56K 256K
List (:30) 56K 256K
Patrick and Omar (:30) 56K 256K
Craig and Tanya (:30) 56K 256K
17th Century (:45) 56K 256K
The Random Segue (:20) 56K 256K
The Passive Aggressive Mutter (:30) 56K 256K
The Faux Technical Disguise (:30) 56K 256K
The Overzealous Blurt (:20) 56K 256K
Alex (:30)
Andrew (:30)
Charlotte (:30)
Patricia (:20)
Questions (:30)

2004

Skate Dawgs (:45)
Roommates (:30)
Volleyball (:60)
Action (:30)
Horror Film (:30)
Couch (:30)
Couch (:10)
Hallway (:10) 
Bedroom (:30)

2003

Condom Factory (:30)
Condom Testing (:30)
Poet's Cafe (:45)
Tattoo (:25)
Piercing (:25)
Showdown (:45)
Condom Machine (:30)
Everything But (:30)
Freezing (:30)
Deli (:50)
Drug Store (:50)
Night Kids (:50)

2002

Gym Class (:30)
Computer Class (:30)
Home Ec (:30)
Sex in the High School (:30)
Locker Room (:30)
Living Room (:30)
Pharmacy (:30)
Assume Everyone is Positive (:15) 
Doesn't Have to Happen (:30)
Risk (:30)
Communication (:15)
Empowerment (:15)
Protection (:30)
Safe Sex (:15)
One at a Time (:30)
Airport Security (:30)
Crap You've Heard Somewhere: If my doctor didn't ask me about STDs... (phone number) (:15)
Crap You've Heard Somewhere: You can't get pregnant the first time... (website) (:15)
Crap You've Heard Somewhere: I can tell who has an STD (phone number) (:15)
Crap You've Heard Somewhere: If you use condoms some of the time... (website) (:15)
Crap You've Heard Somewhere: If you're careful... (phone number) (:15)
Crap You've Heard Somewhere: If your condom breaks... (website) (:15)
Crap You've Heard Somewhere: If you're having your period... (phone number) (:15)
Crap You've Heard Somewhere: If I had an STD I would know (website) (:15)
Crap You've Heard Somewhere: I don't sleep around... (phone number) (:15)
Crap You've Heard Somewhere: Oral Sex (website) (:15)

2001

Convenience Store (:30)
Girls Who Talk (:30)
Girls Who Tease (:30)
Boys Who Talk (:30)
Boys Who Tease (:30)
Gameshow (Spanish) (:30)
Beauty Contest (Spanish) (:30)
Assembly (:30)
Football (:30)
Nightclub (:30)